Cancer

Modulation Of Upa, Mmps And Their Inhibitors By A Novel Nutrient Mixture In Human Colorectal, Pancreatic And Hepatic Carcinoma Cell Lines

Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M

Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
International Journal of Oncology –2015; 47(1): 370-376

Abstract:

Colorectal, pancreatic and hepatic carcinomas are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the ECM and basement membrane, allowing cancer cells to spread to distal organs. Proteases play a key role in tumor cell invasion and metastasis by digesting the basement membrane and ECM components. Strong clinical and experimental evidence demonstrates association of elevated levels of uPA and MMPs with cancer progression, metastasis and shortened patient survival.

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Micronutrient Synergy in the Fight Against Hepatocellular Carcinoma

M. W. Roomi, N. W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050, USA
Cancers 2012, 4(2):323-339

Abstract: 
The incidence of hepatocellular carcinoma (HCC), once thought to be a rare tumor in North America, has rapidly increased in recent years in the United States. Current treatment modalities to halt the progression of this disease are only marginally effective. The mainstay treatment is liver transplantation, which is often confronted with donor shortage. Invasion, metastasis and recurrence contribute to the high mortality rate of this disease. Matrix metalloproteinases (MMPs) that degrade the extracellular matrix (ECM) have been associated with the progression, invasion and metastasis of the disease.

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In Vivo and In Vitro Effect of a Nutrient Mixture of Chemopreventive Agents on Human Hepatocarcinoma Cells

M.W. Roomi, N.W. Roomi, T. Kalinovsky, A. Niedzwiecki and M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050

Exp Oncol 2010, 32: 84-91

Abstract

Purpose: Long-term survival of patients with hepatocellular carcinoma (HCC), a common cancer worldwide, remains poor, due to metastasis and recurrence. We investigated the effect of a novel nutrient mixture (NM) of chemopreventive agents containing ascorbic acid, lysine, proline, and green tea extract on human HCC cell line Sk-Hep-1 in vivo and in vitro.

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Antitumor Effect of a Combination of Lysine, Proline, Arginine, Ascorbic Acid, and Green Tea Extract on Pancreatic Cancer Cell Line MIA PaCa-2

M.W.Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Gastrointestinal Cancer 2005, 35(2): 97-102.

Background:
Current treatment of pancreatic cancer is generally associated with poor prognosis, even if diagnosed early, due to aggressive rate of metastasis and non-responsiveness to chemotherapy and radiotherapy. Matrix metalloproteinases (MMPs) have received much attention in recent years for their role in various malignancies, and have been implicated in tumor invasion, metastasis and angiogenesis.

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In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Colon Cancer Cell HCT 116 Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry

M.W. Roomi, V.Ivanov, T.Kalinovsky, A. Niedzwiecki, M.Rath
Oncology Reports 2005, 12(3): 421-425

Abstract:
Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. MMPs, VEGF, Ki 67 (proliferative protein), and constituents of ECM, such as fibronectin, play a critical role in angiogenesis and are thus crucial in neoplastic invasion and metastasis.

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