Nutraceuticals In Cancer Prevention(Chapter 11)

M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki

Dr. Rath Research Institute,1260 Memorex Drive, Santa Clara, CA 95050

Nutraceuticals – Efficacy, Safety and Toxicity, ed. R.C. Gupta, Elsevier 2016, pp 135-144


The mainstays of cancer treatment are surgery, chemotherapy, radiation and immunotherapy. Although each has benefits, none of them is ideal, because with all these strategies the quality of life is compromised. Therefore, it is not surprising that 80% of cancer patients seek alternative therapy, which includes antioxidants and other essential micronutrients. We have developed new approaches to prevent cancer development, progression and metastasis using naturally occurring micronutrients containing lysine, proline, ascorbic acid and green tea extract (NM) that act synergistically by strengthening collagen and connective tissue.

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Anticancer Efficacy Of Polyphenols And Their Combinations

Aleksandra Niedzwiecki, Mohd Waheed Roomi, Tatiana Kalinovsky, Matthias Rath

Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Nutrients   2016, 8, 552; DOI: 10.3390/nu8090552


Polyphenols, found abundantly in plants, display many anticarcinogenic properties including their inhibitory effects on cancer cell proliferation, tumor growth, angiogenesis, metastasis, and inflammation as well as inducing apoptosis. In addition, they can modulate immune system response and protect normal cells against free radical damage. Most investigations on anticancer mechanisms of polyphenols were conducted with individual compounds. However, several studies, including ours, have indicated that anti-cancer efficacy and scope of action can be further enhanced by combining them synergistically with chemically similar or different compounds. While most studies investigated the anti-cancer effects of combinations of two or three compounds, we used more comprehensive mixtures of specific polyphenols and mixtures of polyphenols with vitamins, amino acids and other micronutrients.

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A specific combination of ascorbic acid, lysine, proline and epigallocatechin gallate inhibits proliferation and extracellular matrix Invasion of various human cancer cell lines

S.P. Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Research Communications in Pharmacology and Toxicology, Emerging Drugs 2003; Vol. II, IV37-IV50

We found that a specific combination of ascorbic acid (AA, 100µM), proline (P, 140 µM) and lysine (L, 400 µM) had a significant antiproliferative and antimetastatic effect against some human cancer cell lines, breast (MDA-MB-231), colon (HCT116) and skin (melanoma, A2058). In the presence of this nutrient combination the invasion of the extracellular matrix by human breast cancer cells, melanoma cells and colon cancer cells was inhibited by 50%, 10% and 30% respectively. Addition of epigallocatechin gallate (EGCG) further enhanced this nutritional synergy producing a more pronounced inhibitory effect on both cellular proliferation and matrix invasion.

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