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Anticancer Effects of a Micronutrient Mixture on Melanoma: Modulation of Metastasis and Other Critical Parameters

Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M
Breakthroughs in Melanoma Research, ed. Y. Tanaka, In Tech Publisher, 2011, Ch 26,  pp 559-574

Abstract:
Consumption of a plant-based diet has been associated with prevention of the development and progression of cancer. We have developed strategies to inhibit cancer development and its spread by targeting common mechanisms used by all types of cancer cells that decrease stability and integrity of connective tissue. Our approach to strengthening of collagen and connective tissue compromised in cancer metastasis , tumor growth and angiogenesis has been based on using specific natural components, among them  lysine, proline, ascorbic acid and green tea extract (NM). We have documented synergistic effects of this micronutrient mixture and its effectiveness in controlling key mechanisms of cancer  in vivo and in vitro in a wide variety of cancer cell lines.

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Ascorbate Depletion Increases Growth and Metastasis of Melanoma Cells in Vitamin C Deficient Mice

J. Cha, M.W. Roomi, V. Ivanov, T.Kalinovsky, A.Niedzwiecki, M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Experimental Oncology 2011, 33(4):1-5

Abstract:
Melanoma, an aggressive skin cancer, causes the most skin cancer-related deaths, due to metastasis to other areas of the body, Degradation of the extracellular matrix plays a critical role in the formation of tumors and metastasis and has been found to correlate with the aggressiveness of tumor growth and invasiveness of the cancer. Vitamin C, synthesized by many animals but not by humans, is known to be essential for the structural integrity of the intercellular matrix. Humans must obtain ascorbate by diet and cancer patients have been shown to have very low reserves of vitamin C.

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Inhibition of 7,12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture

M.W. Roomi, N.W. Roomi, T. Kalinovsky, V. Ivanov, M. Rath, A. Niedzwiecki
Medical Oncology 2008, 25(3): 333-340

Abstract:
The annual incidence of all forms of skin cancer, the most common of all human cancers, is increasing yearly. A unique nutrient mixture (NM) was shown to exhibit anticancer activity in vivo and in vitro. We examined the effect of NM on the development of skin cancer induced by 7,12-dimethylbezanthracene (DMBA) in female SENCAR mice by a complete carcinogenesis protocol. Mice (n = 55) were divided into four groups and carefully shaved on dorsum.

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Suppression of growth and hepatic metastasis of murine B16FO melanoma cells by a novel nutrient mixture

M.W. Roomi, T. Kalinovsky, N.W. Roomi, V. Ivanov, M. Rath M, A. Niedzwiecki
Oncology Reports 2008; 20(4): 809-817

Highly metastatic melanoma is resistant to existing therapies. Our main objective was to investigate the effect of a nutrient mixture (NM) on B16FO tumor growth and hepatic metastasis. Tumor growth was studied in athymic nude male mice, 5-6 weeks old, inoculated with 106 B16FO melanoma cells subcutaneously and fed either a regular diet or one supplemented with 0.5% NM. Four weeks later, the mice were sacrificed and their tumors were excised, weighed and processed for histology. Metastasis was studied in C57BL/6 mice, which received 106 B16FO melanoma cells by intrasplenic injection and a regular diet or one supplemented with NM 0.5% for 2 weeks.

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In Vitro and In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, And Green Tea Extract On Human Melanoma Cell Line A2058

M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
In Vivo 2006; 20(1):25-32

Introduction:
Melanoma, a very serious form of skin cancer, causes the most skin cancer-related deaths, due to metastasis. Structural changes in the ECM are necessary for cell migration during tissue remodeling. MMPs, VEGF, Ki 67 (proliferative protein), and constituents of ECM play a critical role in angiogenesis, and are crucial in neoplastic invasion and metastasis. Based on antitumor properties of certain nutrients, we investigated the effect of a diet containing lysine, proline, arginine, ascorbic acid, and green tea extract on the growth of tumors induced by implanting human melanoma A2058 cells in athymic nude mice and on the expression of MMPs, VEGF, Ki 67 and fibronectin in these tumors, as well as the production of mucin (by PAS staining).

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