After heart disease, cancer is the second leading cause of death worldwide. One in two men and one in three women will be diagnosed with some type of cancer in their lifetime. Despite novel initiatives, the American Cancer Society estimates that by 2020 the number of new cancers will increase to more than one million cases per year in men, and more than 900,000 cases per year in women. Melanoma, lung, breast, and prostate cancer are the most commonly diagnosed among the new cancers. Although cigarette smoking - the most common risk factor for cancer - still remains high, obesity and other metabolic disorders can contribute to and increase breast, colon, uterus, pancreas, and kidney cancers.