Modulation Of Upa, Mmps And Their Inhibitors By A Novel Nutrient Mixture In Human Colorectal, Pancreatic And Hepatic Carcinoma Cell Lines

Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M

Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
International Journal of Oncology –2015 DOI: 10.3892/ijo.2015.3008


Colorectal, pancreatic and hepatic carcinomas are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the ECM and basement membrane, allowing cancer cells to spread to distal organs. Proteases play a key role in tumor cell invasion and metastasis by digesting the basement membrane and ECM components. Strong clinical and experimental evidence demonstrates association of elevated levels of uPA and MMPs with cancer progression, metastasis and shortened patient survival.

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Antitumor Effect of a Combination of Lysine, Proline, Arginine, Ascorbic Acid, and Green Tea Extract on Pancreatic Cancer Cell Line MIA PaCa-2

M.W.Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Gastrointestinal Cancer 2005, 35(2): 97-102.

Current treatment of pancreatic cancer is generally associated with poor prognosis, even if diagnosed early, due to aggressive rate of metastasis and non-responsiveness to chemotherapy and radiotherapy. Matrix metalloproteinases (MMPs) have received much attention in recent years for their role in various malignancies, and have been implicated in tumor invasion, metastasis and angiogenesis.

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