Anticancer Efficacy Of Polyphenols And Their Combinations

Aleksandra Niedzwiecki, Mohd Waheed Roomi, Tatiana Kalinovsky, Matthias Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Nutrients   2016, 8, 552; DOI: 10.3390/nu8090552

Abstract:

Polyphenols, found abundantly in plants, display many anticarcinogenic properties including their inhibitory effects on cancer cell proliferation, tumor growth, angiogenesis, metastasis, and inflammation as well as inducing apoptosis. In addition, they can modulate immune system response and protect normal cells against free radical damage. Most investigations on anticancer mechanisms of polyphenols were conducted with individual compounds. However, several studies, including ours, have indicated that anti-cancer efficacy and scope of action can be further enhanced by combining them synergistically with chemically similar or different compounds. While most studies investigated the anti-cancer effects of combinations of two or three compounds, we used more comprehensive mixtures of specific polyphenols and mixtures of polyphenols with vitamins, amino acids and other micronutrients.

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Failure Of Mmp-9 Dimer Induction By Pma In Normal Human Cell Lines

M.W. Roomi, T. Kalinovsky, M. Rath and A. Niedzwiecki
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Oncology Letters 2015 DOI: 10.3892/ol.2015.3132

Abstract:

Strong clinical and experimental evidence demonstrates association of elevated levels of matrix metalloproteinase MMP-9 with cancer progression, metastasis and shortened patient survival, as it plays a key role in tumor cell invasion and metastasis by digesting the basement membrane and ECM components. MMP-9 is secreted in both the monomeric and dimeric form. Though there is little research on MMP-9 dimers, some studies have shown the dimer to be associated with more aggressive tumor progression as cell migration depends upon MMP-9 dimer, not the monomer.

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Effect of a nutrient mixture on matrix metalloproteinase-9 dimers in various human cancer cell lines

M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki 
Dr. Rath Research Institute, Santa Clara, CA
International Journal of Oncology 2013, DOI: 10.3892/ijo.2013.2235

Abstract: 
Strong clinical and experimental evidence demonstrates association of elevated levels of matrix metalloproteinase MMP-9 with cancer progression, metastasis and shortened patient survival, as it plays a key role in tumor cell invasion and metastasis by digesting the basement membrane and ECM components. MMP-9 is secreted in both the monomeric and dimeric form. Though there is little research on MMP-9 dimers, some studies have shown the dimer to be associated with more aggressive tumor progression. Our objective was to study the relative secretion patterns of MMP-9 monomer and dimer by a variety of cancer cell lines and the effect of a nutrient mixture (NM) containing lysine, proline, ascorbic acid and green tea extract on MMP-9 secretion. 

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Suppression of metastasis of intratesticular inoculation of B16FO melanoma cells by a novel nutrient mixture in male athymic nude mice

M.W. Roomi, T. Kalinovsky, N.W. Roomi,  A. Niedzwiecki and M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Experimental and Therapeutic Medicine 2012, DOI:10:3892/etm.2012.689

Abstract:
Metastasis, commonly to the lung, is the major cause of death from testicular cancer. We studied the effect of a novel nutrient mixture (NM) containing ascorbic acid, amino acids and green tea extract on inhibition of melanoma growth and metastasis using a model of intratesticular inoculation of B16FO cells into nude mice. Male athymic mice (n=12), 10-12 weeks of age, were inoculated with 5X105 B16FO melanoma cells in 100 µL of PBS into the right testis; the left testis was left untreated. After inoculation, the mice were randomly divided into two groups. The Control group (n=6) was fed a regular mouse chow diet and the NM 1% group (n=6) the same diet but supplemented with 1% NM. Four weeks later the mice were sacrificed and the abdominal cavity was opened.

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Micronutrient Synergy – a New Tool in Effective Control of Metastasis and Other Key Mechanisms of Cancer

A. Niedzwiecki, M.W. Roomi, T. Kalinovsky, M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050

Cancer and Metastasis Reviews 2010; 29(3): 529-542

Abstract
Consumption of a plant-based diet has been associated with prevention of the development and progression of cancer. We have developed strategies to inhibit cancer development and its spread by targeting common mechanisms used by all types of cancer cells that decrease stability and integrity of connective tissue. Strengthening of collagen and connective tissue can be achieved naturally through the synergistic effects of selected nutrients, such as lysine, proline, ascorbic acid and green tea extract (NM). This micronutrient mixture has exhibited a potent anticancer activity in vivo and in vitro in a few dozen cancer cell lines. Its anti-cancer effects include inhibition of metastasis, tumor growth, MMP secretion, invasion, angiogenesis and cell growth as well as induction of apoptosis

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