Other Aspects of Cancer

Scientific evaluation of dietary factors in cancer

M.W. Roomi, A. Niedzwiecki, Ph.D., M. Rath, M.D.

Dr. Rath Research Institute,  1260 Memorex Drive, Santa Clara, CA 95050

J Nutri Med Diet Care 2018, 4:029

Abstract: 

Epidemiological and experimental studies suggest that a proper diet and a healthy life style can decrease the risk of cancer by up to 70%. The cancers most closely related to nutrition are breast and endometrial cancers in women and prostate and gastrointestinal cancers in men.
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Induction of Apoptosis in Human Lung Cancer Cells (A-549) by a Novel Nutrient Mixture via Upregulation of Caspase Enzymes

M.W. Roomi, Ph.D., Ahmed T, A. Niedzwiecki, Ph.D., M. Rath, M.D.

Dr. Rath Research Institute,  1260 Memorex Drive, Santa Clara, CA 95050

Austin J Lung Cancer Res. 2018; 3(1): 1013 – 1016

Abstract: 

Lung cancer is the leading cause of death in western world, and the incidence continues to increase. Lung cancer is frequently diagnosed when it is extensively metastasized and has a dismal prognosis. Chemotherapy being the mainstay of treatment has not been able to increase quality of life or survival of patients. A novel nutrient mixture containing green tea extract, ascorbic acid, lysine, and proline exhibited anti-cancer effects in various cancers. In our earlier studies, the nutrient mixture considerably reduced the tumor weight and tumor burden in athymic mice using A-549 lung cancer cells.
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Peptide vaccines directed against human Metalloproteinases (MMPs) with anti-tumor efficacy in vitro and in vivo

M.W. Roomi, Ph.D., A. Niedzwiecki, Ph.D., M. Rath, M.D.

Dr. Rath Research Institute,  1260 Memorex Drive, Santa Clara, CA 95050

Journal of Cellular Medicine and Natural Health

Abstract: 

Despite sporadic progress, cancer has thus far eluded preventive and therapeutic approaches that can lead to an effective control of this global epidemic. The single most important reason for this failure is the fact that no effective intervention became available to impede the pathological pathways common to all types of cancer. In our study, we targeted metalloproteinases (MMPS), endopeptidases that are involved in the breakdown of extracellular matrix (ECM). Among them, MMP-2 and MMP-9 are critically involved in all stages of cancer development including tumor growth, invasion and metastasis.

Our goal was to develop an anti-cancer vaccine by inhibiting these specific enzymes. We selected three oligopeptides from human MMP-9 and one from human MMP-2. We demonstrated the efficacy of these oligopeptides in generating immune response in mice. The  in vitro tests showed that anti-MMPs sera were effective in curbing invasion of HeLA cells through the extracellular matrix system (Matrigel).

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Down regulation of u-Pa by a nutrient mixture In hemangioma (eoma) cells by inducing Caspase-dependent apoptosis

M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki

Oncology Division, Dr. Rath Research Institute,1260 Memorex Drive, Santa Clara, CA 95050

Nutraceuticals – Efficacy, Safety and Toxicity, ed. R.C. Gupta, Elsevier 2016, pp 135-144

Abstract: 

Hemangiomas are the most common congenital vascular and benign tumor in infants and children. Most hemangiomas do not cause major symptoms to require intervention, however, the larger hemangiomas have tendency to bleed and may require surgical removal. Experimental studies have demonstrated the role of urokinase plasminogen activator (u-PA), especially cell surface u-PA, as an initiator of extra-cellular matrix proteolysis and associated tumor cell invasion.

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Nutraceuticals In Cancer Prevention(Chapter 11)

M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki

Dr. Rath Research Institute,1260 Memorex Drive, Santa Clara, CA 95050

Nutraceuticals – Efficacy, Safety and Toxicity, ed. R.C. Gupta, Elsevier 2016, pp 135-144

Abstract: 

The mainstays of cancer treatment are surgery, chemotherapy, radiation and immunotherapy. Although each has benefits, none of them is ideal, because with all these strategies the quality of life is compromised. Therefore, it is not surprising that 80% of cancer patients seek alternative therapy, which includes antioxidants and other essential micronutrients. We have developed new approaches to prevent cancer development, progression and metastasis using naturally occurring micronutrients containing lysine, proline, ascorbic acid and green tea extract (NM) that act synergistically by strengthening collagen and connective tissue.

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