Head and neck cancers are a group of tumors originating from several areas above the collarbone. They include cancers of the larynx, salivary glands, tongue, thyroid, and nasopharyngeal area. Annually there are 60,000 new cases of head and neck squamous cell carcinoma (HNSCC) in the US, and more than 13,000 deaths. Squamous cells are a type of cells found in the outer layer of the skin and in the mucous membranes and include the cells lining airways and intestines.
The biggest risk factor for head and neck cancers include tobacco use and smoking (this includes the smokeless tobacco), and alcohol - all of which are highly preventable causes. Additionally, sun exposure, and occupational exposure to substances like chromium, radium, leather, and wood dust can also increase the risk of developing HNSCC. Hence, the ears, nose, and throat happen to be the most common affected areas.
In the last issue of the Health Science News Page we described the causes and effects of diabetes in children. Typically, type 1 diabetes affects children. However, due to poor diet and increasing obesity, type 2 diabetes is becoming common in children. While insulin and metformin are the FDA approved drugs for diabetic children, many other drugs are also used that are not tested in the younger population and, other safer avenues of addressing diabetic-related health issues are not emphasized enough.
Diabetes is one of the most common non-communicable diseases worldwide. It is no longer a disease of the ageing population in developed countries. Diabetes or pre-diabetes is increasingly being diagnosed in the younger population everywhere and most markedly in developing countries. Diabetes has reached epidemic proportions worldwide and this disease is at the forefront of public health challenges the world faces this century. The number of people around the world living with diabetes has skyrocketed in the last few decades and 422 million people were diagnosed with diabetes in 2014.
Ovarian Cancer is the fifth leading cause of cancer deaths in the USA, and is the deadliest of gynecological cancers in women. According to the 2016 estimates of the American Cancer Society, 22,280 women will be diagnosed with ovarian cancer in the United States and 14,240 women will die from this disease. The main reason for such high death rate is that ovarian cancer is often diagnosed when the disease has already progressed. Unfortunately, there are no specific symptoms pointing to ovarian cancer. A woman can have an array of vague symptoms such as dull abdominal pain, feeling of fullness or bloating, changed bowel habits, indigestion, loss of appetite and weight loss. Sometimes, an abdominal mass may also be present. This non-specificity of symptoms helps explain why the majority of women are diagnosed when the cancer has already spread to the pelvis, abdominal organs, the liver and the lungs.
Osteoporosis - or thinning of bones- is a condition affecting 200 million people worldwide. This figure includes both women and men over 50. Approximately 75 million of those affected are in the USA, Europe, and Japan. Although postmenopausal women are more likely to develop osteoporosis, one in five men will also develop significant bone thinning in their lifetime. Osteoporosis is a disease where the bones lose density and strength which increases the risk of fractures and debilitation. Osteoporosis is the most common - yet least detected - bone metabolism disorder. A sedentary lifestyle, the use of prescription drugs such as corticosteroids, antacids (specifically, proton pump inhibitors), and psychiatric medications can cause excessive bone loss leading to osteoporosis. In the elderly, thin bones are prone to breaking and can result in hip or vertebral fractures and can increase the risk of premature death.
The human skeletal system is made up of bones and joints. It provides support and mobility, and protects the body’s organs. We are born with more than 300 bones. Many of them fuse together during childhood and an adult human being eventually has 206 bones. The largest bone in the human body is the femur (thigh bone) and the smallest bones in the human body are the three bones of the middle ear. Maximum bone growth occurs during childhood and puberty and tapers off at 16-18 years of age. While the bones do not grow in size after 18-20 years, they are not stagnant, hard, and inert structures. A continuous metabolic process called bone remodeling occurs within the bones throughout our life. This is an essential lifelong process during which the bone is resorbed and formed again by specialized cells in the skeletal system. Osteoclasts break down mineralized bone and participate in the bone reabsorption process, and osteoblasts build bone. Our entire skeleton is renewed every few years and it is estimated that at any time about 20% of an adult bone is undergoing remodeling.
Sugar is required for production of bioenergy and other metabolic processes taking place in our body cells. Though sugar is an important part of our diet, the simple fact is that our consumption of sugar largely exceeds our body’s metabolic needs. The modern diet contains approximately 50-80 grams of sugar and most of it is derived from fructose. Fructose is metabolized differently in the body than glucose is. Present in soft drinks and most types of processed food and sweets, the consequences of excessive fructose consumption are dangerous and it has been associated with an increase in diabetes, heart disease and many other health problems.
Our last issue of our Health Science News Page focused on polyphenols, which are the nutrient compounds present in various plants that help in protecting plants from insects, diseases, pollutants, and damage from ultraviolet rays. In Part 1 we discussed a few of the important and most researched polyphenols - specifically quercetin, curcumin, green tea extract, and resveratrol - and their actions and functions in the human body.
Phytonutrients are natural components of plants with important functions such as protecting plants from insects, diseases, draught, ultraviolet rays, and pollutants. The best known phytonutrients are the polyphenols, carotenoids, flavonoids, catechins, and isoflavones. There are various sub-classifications of phytonutrients which include ligans, phenolic acids, and indoles. Flavones are present in vegetables such as parsley and celery, and flavolones are present in tomatoes and other citrus fruits. Catechins are present in fruits, red wine, green tea and chocolate. Ligans are found in various legumes, cereals, grains, and flax seed. In addition to protecting plants against various pathogenic organisms and ultraviolet rays, polyphenols also act as antioxidant and anti-inflammatory agents.
In our last Health Science News Page, we discussed some of the general aspects of the role of micronutrients in pregnancy. The placental development begins in the first weeks when the woman is not even aware she is pregnant. The health of the placenta determines the overall growth and development of the baby throughout the entire course of pregnancy.