Comment

Recent clinical studies have shown that hormone replacement therapy (HRT) in menopausal women increases the risk of tumor development in estrogen-sensitive tissues. In this study, estradiol stimulated breast cancer (MCF-7) cell growth, MMP expression, matrix invasion, and VEGF secretion (measure of angiogenesis) were observed in culture. These pro-carcinogenic effects of estradiol were significantly inhibited by Nutrient Synergy, suggesting this is an excellent candidate for preventative and therapeutic use in the treatment of estrogen-related breast cancer.