- 81. A Novel Nutrient Mixture Induces Apoptosis in Human Ovarian and Cervical Cancer Cells
- (Female Reproductive Cancer)
- ... patients has dropped to 15-20% when these cancers metastasize to distant organs. A unique formulation of nutrients containing green tea extract, ascorbic acid, lysine and proline, has ...
- Created on 28 January 2019
- 82. Peptide vaccines directed against human Metalloproteinases (MMPs) with anti-tumor efficacy in vitro and in vivo
- (Other Aspects of Cancer)
- ... develop an anti-cancer vaccine by inhibiting these specific enzymes. We selected three oligopeptides from human MMP-9 and one from human MMP-2. We demonstrated the efficacy of these oligopeptides in generating ...
- Created on 23 January 2019
- 83. Down regulation of u-Pa by a nutrient mixture In hemangioma (eoma) cells by inducing Caspase-dependent apoptosis
- (Other Aspects of Cancer)
- ... changes than the control or camptothecin-treated cells. Conclusion: These results suggest NM as a potential therapeutic agent as it specifically targets and induces apoptosis in hemangioma cells. Key ...
- Created on 19 June 2018
- 84. Reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms of Borrelia spp.
- (Lyme Disease)
- ... permeability of Borrelia spp. but did not cause DNA damage. Conclusions: These results show that a specific combination of flavones might play a supporting role in combating Borrelia spp. through either ...
- Created on 23 June 2017
- 85. Composition of Plant-derived Compounds as an Alternative Approach to Lyme disease
- (Scientific Presentations: Infectious Diseases)
- ... in vitro tested individually and in combinations against active and persistent forms of B. burgdorferi (prevalent in the USA) and B. garrini (prevalent in Europe). Several of these compounds, individually ...
- Created on 20 June 2017
- 86. In vitro Evaluation of Non-synthetic Compounds against Biofilm of Streptococcus mutans
- (Scientific Presentations: Infectious Diseases)
- ... italicum extract have eradicated 80% of mature biofilm. Moreover, treatments with these agents significantly disrupted EPS content within biofilms validating anti-biofilm action of these compounds. Therefore, ...
- Created on 20 June 2017
- 87. Modulation of MMP-2 and -9 Secretion by Cytokines, Inducers and Inhibitors in Human Melanoma A-2058 Cells
- (Skin Cancer)
- ... inducers and inhibitors control MMP activities. We investigated the roles of these in regulation of MMP-2 and -9 in human melanoma A-2058 cells. Human A-2058 cells were grown in DMEM supplemented with ...
- Created on 26 April 2017
- 88. Nutrient Synergy: A Novel Approach To Head And Neck Cancer (Chapter 1)
- (Head & Neck Cancers)
- ... with progression and invasion of these tumors. In our studies we targeted various mechanisms of cancer by designing specific combinations of different polyphenols (PB) and combinations of polyphenols with ...
- Created on 28 March 2017
- 89. Modulation of MMP-2 and MMP-9 secretion by cytokines, inducers and inhibitors in human glioblastoma T-98G cells
- (Head & Neck Cancers)
- ... to spread to distal organs. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activity. We investigated the roles of these in the regulation of MMP-2 and MMP-9 in human glioblastoma ...
- Created on 28 March 2017
- 90. Cytokines, Inducers And Inhibitors Modulate Mmp-2 And Mmp‑9 Secretion By Human Fanconi Anemia Immortalized Fibroblasts
- (Head & Neck Cancers)
- ... and MMP-9, have been implicated in tumor invasion and metastasis. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activities. We investigated the roles of these in the ...
- Created on 28 March 2017
- 91. A Specific Mixture Of Nutrients Suppresses Ovarian Cancer A-2780 Tumor Incidence, Growth, And Metastasis To Lungs
- (Female Reproductive Cancer)
- ... Matrigel with total block at 250 μg/mL concentration. MTT showed dose-dependent inhibition of cell proliferation with EPQ, and H & E staining showed no morphological changes below 500 μg/mL EPQ. These ...
- Created on 20 March 2017
- 92. In Vitro Modulation of MMP-2 and MMP-9 Secretion by Cytokines, Inducers, and Inhibitors in Head and Neck Squamous Carcinoma Cells (FaDu) and Tongue Carcinoma Cells (SCC-25)
- (Head & Neck Cancers)
- ... and quantitatively analyzed by densitometry. Our results showed that these agents have an up and down regulating effect on MMP-2 and MMP-9 secretion, suggesting the clinical usage of these agents may be ...
- Created on 06 February 2017
- 93. Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes
- (Blood Cancer)
- ... two cell lines. Conclusion: These results indicated that while AA exerted its anti-proliferative effect on the NF- κB activation pathway by suppressing Tax expression, its effects on MMP9 seemed to be ...
- Created on 05 January 2017
- 94. Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia sp
- (Lyme Disease)
- ... be explored further in defining more effective treatments against these bacteria. This article is protected by copyright. All rights reserved. Key Words: Borrelia sp., spirochetes, cysts, biofilm, ...
- Created on 19 September 2016
- 95. The anti-borreliae efficacy of phytochemicals and micronutrients: an update
- (Lyme Disease)
- ... of these bacteria and help improve the efficacy of current approaches against Lyme disease. Here, we review all naturally occurring substances scientifically evaluated to date, including plant extracts, ...
- Created on 19 September 2016
- 96. Lipoprotein(A) And Vitamin C Impair Development Of Breast Cancer Tumors In Lp(A)+; Gulo-/- Mice
- (Breast Cancer)
- ... C synthesis and the production of human Lp(a). Female Lp(a)+;Gulo(-/-) and control wild type Balb/c mice without these two metabolic features were orthotopically inoculated with 4T1 breast cancer cells ...
- Created on 04 July 2016
- 97. Reciprocal Cooperation of Phytochemicals against Borrelia burgdorferi and Borrelia garinii
- (Scientific Presentations: Infectious Diseases)
- ... Antibacterial effects of these agents’ cooperation were evaluated at their MIC values and three dilutions above (2-6 X MIC) as well as three dilutions below their MICs (1/2-1/8 X MIC), according to checkerboard ...
- Created on 20 June 2016
- 98. Evaluation of Vitamin D3 and Vitamin C in Cooperation with Doxycycline against Borrelia burgdorferii and Borrlia garinii
- (Scientific Presentations: Infectious Diseases)
- ... forms of Borrelia burgdorferi and Borrelia garinii using dark field and fluorescence microscope. Synergistic antibacterial effect of these agents was evaluated at their MIC values and three dilutions above ...
- Created on 16 June 2016
- 99. New Non-synthetic Antibacterial Agents Challenging the Active and Persistent Forms of Borrelia ssp.
- (Scientific Presentations: Infectious Diseases)
- ... different persistent forms. Thus, there is a continuous search for new compounds that would be effective not only against spirochetes but also these persisters. Naturally occurring agents signify a growing ...
- Created on 16 May 2016
- 100. Inhibition Of Collagen Synthesis By Select Calcium And Sodium Channel Blockers Can Be Mitigated By Ascorbic Acid And Ascorbyl Palmitate
- (Heart Disease)
- ... with increased mortality and increased risk for myocardial infarction. In addition to the side effects mentioned above by different channel blockers, these drugs can cause arterial wall damage, thereby ...
- Created on 13 May 2016