Chlorophyllin Suppresses Growth, MMP Secretion, Invasion and Cell Migration of Fibrosarcoma Cell LineHT1080

M.W. Roomi, B Bhanap, A Niedzwiecki, M Rath

Department of Oncology, Dr. Rath Research Institute, USA

Medical Research Archives, v. 6, n. 12, dec. 2018.

Abstract: 

Fibrosarcoma is an aggressive and highly malignant cancer of connective tissue with the lung being the most common site of metastasis. Surgery, chemotherapy, and radiation are the mainstay of treatments, yet the prognosis is very poor. A number of plant-based phytochemicals are increasingly being used as important treatment methods of cancers.

Read more ...

A Nutrient Mixture Induces Caspase Dependent Apoptosis in Human Synovial Sarcoma Cells

M.W. Roomi, B Bhanap, Ahmed T, A Niedzwiecki, M Rath

Department of Oncology, Dr. Rath Research Institute, USA

J Sarcoma Res. 2018; 2(1): 1010 -1014

Abstract: 

Synovial sarcoma is a rare soft tissue cancer occurring more frequently in adolescent and young adults than older people. The primary sites being the joints of the arms and the legs.A novel Nutrient Mixture (NM) containing green tea extract, ascorbic acid, lysine, and proline exhibited anti-cancer effects in various cancers. In our earlier studies, the NM considerably reduced the tumor weight and tumor burden in synovial sarcoma.

Read more ...

Anti-cancer potential of a specific mixture of phytonutrients in bone cancer cells

M.W. Roomi, B Bhanap, A Niedzwiecki, M Rath

Journal of Cellular Medicine and Natural Health Oct 2017

Abstract: 

Chondrosarcoma, a malignant tumor of cartilaginous origin, is the most common of the adult primary bone cancers. Forty percent of primary bone cancers are chondrosarcoma. However as chondrosarcoma typically does not respond to radiation and chemotherapy, surgery is the main treatment option. Cancer mortality usually results from the local and distant metastasis. Based on the poor prognosis of chondrosarcoma, we investigated effects of a phytonutrient mixture (PB) containing quercetin, CruciferexTM, curcumin, resveratrol and green tea extract on several parameters associated with the development of this type of cancer.

Read more ...

Apoptosis of Human Fibrosarcoma Cells HT-1080 Triggered by a Novel Nutrient Mixture via Induction of Caspases

M.W. Roomi, B. Bhanap, A. Niedzwiecki, M. Rath

Sarcoma Res Int. 2016; 3(3): 1036

 

Abstract: 

Fibrosarcoma is an aggressive and highly malignant cancer of connective tissue with the lung being the most common site of metastasis. Surgery, chemotherapy, and radiation are the mainstay of treatments, yet the prognosis is very poor. A novel Nutrient Mixture (NM) containing green tea extract, ascorbic acid, lysine, and proline exhibited anti-cancer effects in various cancers.

Read more ...

Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in adult human sarcoma cell lines

M.Waheed Roomi, Tatiana Kalinovsky, Aleksandra Niedzwiecki* and Matthias Rath
Dr. Rath Research Institute, Santa Clara, CA
International Journal of Oncology 2013; 43: 39-49

Abstract: 
Adult sarcomas are highly aggressive tumors that are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the ECM and basement membrane, allowing cancer cells to spread to distal organs. Proteases play a key role in tumor cell invasion and metastasis by digesting the basement membrane and ECM components. Strong clinical and experimental evidence demonstrates association of elevated levels of u-PA and MMPs with cancer progression, metastasis and shortened patient survival. MMP activities are regulated by specific tissue inhibitors of metalloproteinases (TIMPs).

Read more ...