M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Society of Toxicology, San Diego, CA, March 5-9, 2006
The Toxicologists (suppl Toxicological Sciences) 90 (1), Abstract 1398, pg 285, 2006.
Overdosing with acetaminophen, a common over-the-counter analgesic, is often fatal, causing severe liver and kidney damage in humans and animals. We tested the protective effect of a nutrient supplemented diet (0.5% NM) in mice injected ip with acetaminophen (600 mg/kg) using a nutrient mixture that has previously demonstrated therapeutic and chemoprotective properties. The nutrient supplemented mice were protected against acetaminophen-induced liver and kidney damage, while the unsupplemented mice exhibited liver and kidney pathology and associated serum enzyme abnormality. Thus, the nutrient mixture provides protection against acetaminophen-induced hepatic and renal damage.