In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Colon Cancer Cell HCT 116 Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry

M.W. Roomi, V.Ivanov, T.Kalinovsky, A. Niedzwiecki, M.Rath
Oncology Reports 2005, 12(3): 421-425

Abstract:
Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. MMPs, VEGF, Ki 67 (proliferative protein), and constituents of ECM, such as fibronectin, play a critical role in angiogenesis and are thus crucial in neoplastic invasion and metastasis.

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Synergistic Effect of Combination of Lysine, Proline, Arginine, Ascorbic Acid and Epigallocatechin Gallate on Colon Cancer Cell Line HCT 116

M.W. Roomi, V.Ivanov, T.Kalinovsky, A. Niedzwiecki, M.Rath
Journal of the American Nutraceutical Association 2004, 7(2): 40-43

Abstract:
Limitation of current treatment methodologies to control metastasis, as well as the proposed antitumor properties of specific nutrients prompted us to investigate the effect of a specific formulation (NS) of lysine, proline, arginine, ascorbic acid, and epigallocatechin gallate on human colon cancer cells HCT 116 for viability, MMP expression, invasion, and morphology.

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