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Scientific Publications
The Dr. Rath Research Institute is a world leader
in conducting natural health research in cardiovascular disease,
cancer and other chronic health conditions. The research of our
scientific team, led by Dr. Rath and Dr. Niedzwiecki, has been
published in many peer-reviewed scientific journals.
Recent Scientific Papers Published by the Matthias
Rath Research Team
| Heart
Disease |
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Extracellular
Matrix-Mediated Control of Aortic Smooth Muscle Growth and Migration by a Combination of Ascorbic Acid, Lysine,
Proline, and Catechins
- NEW -
Ivanov V, Ivanova S, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M
J Cardiovasc Pharmacol, 2007, 50 (5), 541-547.
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Anti-Atherogenic
Effects of a Mixture of Ascorbic Acid, Lysine, Proline,
Arginine, Cysteine, and Green Tea Phenolics in Human Aortic
Smooth Muscle Cells
Ivanov V, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M
J Cardiovasc Pharmacol, 2007, 49 (3).
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Bioflavonoids
Effectively Inhibit Smooth Muscle Cell-Mediated Contraction
of Collagen Matrix Induced by Angiogtensin-II
Ivanov V, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M
The Journal of Cardiovascular Pharmacology, 2005, 46 (5), 570-6.
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Reduction
In The Frequency Of Arrhythmic Episodes In Patients With
Paroxysmal Atrial Arrhythmia With A Vitamin/Essential Nutrient
Program
Niedzwiecki A, Kalinovsky T, Rath M
JANA, 2005, 8 (3), 21-25.
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Enhancement
of Cardio-Protective Effects and Attenuation of Adverse
Effects of Female Sex Hormones on Cultured Human Vascular
Smooth Muscle Cells by a Combination of Ascorbic Acid, Lysine,
Proline, Arginine, Cysteine, and Epigallocatechin Gallate
Ivanov V, Ivanova S, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M
JANA, 2005, 7 (3), 17-22. |
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A
Nutrient Mixture Containing Ascorbic Acid, Lysine, Proline,
Arginine, Cysteine, and Green Tea Extract Suppresses Autocrine
Inflammatory Response in Cultured Human Aortic Smooth Muscle
Cells
Ivanov V, Ivanova S, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M
Research Communications in Pharmacology
Toxicology, 2004, 9, 3-16. |
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| Cancer
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Ascorbic Acid Induces Apoptosis in Adult T-cell Leukemia
- NEW -
Harakeh S, Diab-Assaf M, Khalife J, Abu-El-Ardat K,
Baydoun E, Niedzwiecki A, El-Sabban M, Rath M
Anticancer Research, 2007, 27, 289-298.
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Inhibition of Cell Invasion and MMP Production by a Nutrient Mixture in Malignant Liposarcoma
Cell Line SW-872
- NEW -
Roomi MW, Ivanov V , Kalinovsky T, Niedzwiecki A, Rath M
Medical Oncology, 2007, 24, 394-401.
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Inhibition of Glioma Cell Line A-172 MMP Activity and Cell Invasion In Vitro by a Nutrient
Mixture
- NEW -
Roomi MW, Ivanov V , Kalinovsky T, Niedzwiecki A, Rath M
Medical Oncology, 2007, 24 (2), 231-238.
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Inhibitory Effect Of A Nutrient Mixture on Human Testicular Cancer Cell Line NT 2/DT
Matrigel Invasion and MMP Activity
- NEW -
Roomi MW, Ivanov V , Kalinovsky T, Niedzwiecki A, Rath M
Medical Oncology, 2007, 24 (2), 183-188.
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Naturally Produced Extracellular Matrix Inhibits Growth Rate and Invasiveness of Human
Osteosarcoma Cancer Cells
- NEW -
Ivanov V, Ivanova S, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M
Medical Oncology, 2007, 24 (2), 209-217.
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In vitro anticarcinogenic effect of a nutrient mixture
on human rhabdomyosarcoma cells
Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A,
Rath M
Gene Therapy and Molecular Biology, 2007, 11, 133-141.
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A novel mixture containing ascorbic acid, Lysine, proline, and green tea extracts inhibits
critical parameters in angiogenesis
Roomi MW, Ivanov V, Kalinovsky T,
Niedzwiecki A, Rath M
In Anti-Angiogenic Functional and Medicinal Foods, 2007, Losso JN, Shahidi F, Bagchi D (eds),
CRC Press, Boca Raton, London, New York, 561-580.
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Mechanistic Aspects of Apoptosis Induction by L-Lysine in both HTLV-1-positive and -negative
Cell Lines
- NEW -
Harakeh S, Diab-Assaf M, Abu-El-Ardat K, Niedzwiecki A, Rath M
Chemico-Biological Interactions, 2006, 164, 102-114.
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Inhibition of Pulmonary Metatasis of Melanoma B16FO Cells
in C57BL/6 Mice by a Nutrient Mixture Consisting of Ascorbic
Acid, Lysine, Proline, Arginine, and Green Tea Extract
Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M
Experimental Lung Research, 2006, 32, 1-13.
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In Vivo and In Vitro Anti-tumor Effect of
a Unique Nutrient Mixture on Lung Cancer Cell Line A-549
Roomi MW, Ivanov V, Kalinovsky T, Aleksandra Niedzwiecki,
Rath M
Experimental Lung Research, 2006, 32, 1-13.
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Inhibition
of Matrix Metalloprotenase-2 Secretion and Invasion by Human
Ovarian Cancer Line SK-OV-3 with Lysine,Proline, Arginine,
Ascorbic Acid and Green Tea Extract
Roomi MW, Ivanov V, Kalinovsky T,
Niedzwiecki A,
Rath M
Journal of Obstetrics and Gynecology, 2006, 32 (2), 148-154.
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Anticancer Effect of Lysine, Proline, Arginine, Ascorbic Acid
and Green Tea Extract on Human Renal Adenocarcinoma Line 786-0
Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M
Oncology Reports, 2006, 16 (5), 943-7.
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Effect
of Ascorbic Acid, Lysine, Proline and Green Tea Extract on
Human Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice
Roomi MW,
Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M
Medical Oncology, 2006, 23 (3), 411-417.
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In
Vitro and In Vivo Antitumor Effect of a Nutrient
Mixture Containing Ascorbic Acid, Lysine, Proline, and Green
Tea Extract on Human Synovial Sarcoma Cancer Cells
Roomi MW,
Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M
JANA, 2006, 9 (2), 30-34.
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Inhibition
of Malignant Mesothelioma Cell Matrix Metalloproteinase Production
and Invasion by a Novel Nutrient mixture
Roomi MW, Ivanov V,
Kalinovsky T, Niedzwiecki A, Rath M
Experimental Lung Research, 2006, 32, 69-79.
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Suppression
of Human Cervical Cancer Cell Lines Hela and DoTc2 4510 MMP
Expression and Matrigel Invasion by a mixture of lysine, proline,
ascorbic acid, and green tea extract
Roomi MW, Ivanov V, Kalinovsky T,
Niedzwiecki A, Rath M
Int J Gynecol Cancer, 2006, 16, 1241-1247.
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Anti-tumor
Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green
Tea Extract on Bladder Cancer Cell Line T-24
Roomi MW, Ivanov V,
Kalinovsky T, Niedzwiecki A, Rath M
International Journal of Urology, 2006, 13, 413-417.
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Modulation of Human Renal Cel Carcinoma 786-0 MMP-2 and MMP-9
Activity by Inhibitors and Inducers in Vitro
Roomi MW, Roomi N,
Ivanov V,Kalinovsky T, Niedzwiecki A,
Rath M
Medical Oncology, 2006, 23 (2), 245-250.
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In
Vivo and In Vitro Antitumor Effect of Ascorbic
Acid, Lysine, Proline, Arginine, and Green Tea Extract on
Human Fibrosarcoma Cells HT-1080
Roomi MW, Ivanov V, Kalinovsky T,
Niedzwiecki A, Rath M
Medical Oncology, 2006, 23 (1),105-112. |
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In
Vitro and In Vivo Antitumor Effect of Ascorbic
Acid, Lysine, Proline, And Green Tea Extract On Human Melanoma
Cell Line A2058
Roomi MW, Roomi N, Ivanov V, Kalinovsky T,
Niedzwiecki A, Rath M
In Vivo, 2006, 20 (1), 25-32.
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Anti-Angiogenic
Effects of a Nutrient Mixture on Human Umbilical Vein Endothelial
Cells
Roomi MW, Roomi N, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M
Oncology Reports, 2005, 14, 1399-1404. |
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Apoptosis
Induction by Nutrient Synergy in HTLV-1 Positive and Negative
Malignant T-Cells
Harakeh S, Diab-Assaf M, Niedzwiecki A, Khalife J,
Abu-El-Ardat K, Rath M
Leukemia Research,
2006, 30, 869-881. |
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Inhibitory
Effect Of A Mixture Containing Ascorbic Acid, Lysine, Proline,
And Green Tea Extract On Critical Parameters In Angiogenesis
Roomi MW, Roomi N, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M
Oncology Reports, 2005, 14 (4), 807-815. |
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In
Vitro and In Vivo Antitumorigenic Activity of a Mixture of
Lysine, Proline, Ascorbic Acid and Green Tea Extract on Human
Breast Cancer Lines MDA MB-231 and MCF-7
M.W.
Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology 2005, 22(2),
129-38. |
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Antitumor
Effect of a Combination of Lysine, Proline, Arginine, Ascorbic
Acid, and Green Tea Extract on Pancreatic Cancer Cell Line
MIA PaCa-2
M.W. Roomi, V. Ivanov,
T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Gastrointestinal Cancer,
2005, 35 (2), 97-102. |
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Antitumor
Effect of Nutrient Synergy on Human Osteosarcoma Cells U2OS,
MNNG-HOS, and Ewing’s Sarcoma SK-ES.1
M.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki, M. Rath
Oncology
Reports, 2005, 13 (2), 253-257. |
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Modulation
of N-Methyl –N-Nitrosourea-Induced Mammary Tumors in
Sprague-Dawley Rats by Combination of Lysine, Proline, Arginine,
Ascorbic Acid and Green Tea Extract
M.W.
Roomi, V. Ivanov ,T. Kalinovsky, A. Niedzwiecki, M. Rath
Breast Cancer Research, 2005,
7:R291-R295. |
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In
Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline,
and Green Tea Extract on Human Prostate Cancer PC-3 Xenografts
in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry
M.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki, M. Rath
In Vivo, 2005, 19 (1),
179-184. |
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In
Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline,
and Green Tea Extract on Human Colon Cancer Cell HCT 116
Xenografts in Nude Mice: Evaluation of Tumor Growth and
Immunohistochemistry
M.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki, M. Rath
Oncology Reports, 2005,
12 (3), 421-425. |
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Antitumor
Effect of Ascorbic Acid, Lysine, Proline, Arginine and Epigallocatechin
Gallate in Prostate Cancer Cell Lines PC-3, LNCaP, and DU145
M.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki, M. Rath
Research
Communications in Molecular Pathology and Pharmacology,
2004, 115-116. |
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Synergistic
Effect of Combination of Lysine, Proline, Arginine, Ascorbic
Acid and Epigallocatechin Gallate on Colon Cancer Cell Line
HCT 116
M.W. Roomi, V.
Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Journal
of the American Nutraceutical Association, 2004, 7 (2). |
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In
Vivo and In Vitro Antitumor Effect of Nutrient Synergy on
Human Osteosarcoma Cell Line MNNG-HOS
M.W.
Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Annals of Cancer Research and Therapy,
2004, 12 (1-2). |
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Synergistic
Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Epigallocatechin
Gallate on Human Fibrosarcoma Cells HT-1080
M.W. Roomi, V. Ivanov, T. Kalinovsky,
A. Niedzwiecki, M. Rath
Annals
of Cancer Research and Therapy, 2004, 12 (1-2). |
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| Other
Research |
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Holistic
efficacy of specific nutrient synergy against avian flu virus:
pathology and immunomodulation
- NEW -
Elie K. Barbour, Edward G. Rayya, Houssam
A. Shaib, Rindala G. El Hakim, Afif M. Abdel Nour, Aleksandra
Niedzwiecki, Steve Harakeh & Matthias Rath
Veterinaria Italiana, 43 (1), 43-54 |
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Natural
Nutrient Mixture Effectively Reduces Collagen Matrix Contraction
Driven by Human Uterine Smooth Muscle Cells
- NEW -
V. Ivanov, M.W. Roomi,
T. Kalinovsky, A. Niedzwiecki, M.Rath
Journal
of Obstetrics and Gynaecology Research –2006, 32(1):23-31 |
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Reduction
in Tibial Shaft Fracture Healing Time With Essential Nutrient
Supplementation Containing Ascorbic Acid, Lysine, and Proline
Jamdar J, Rao B, Netke S, Roomi MW, Ivanov
V, Niedzwiecki A, Rath M.
“Letter
to the Editor” (4 pg) by Journal of Alternative
and Complementary Medicine, 2004, 10 (6), 915-916. |
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Dr. Rath's Leading Publications:
The Basis for Cellular Medicine
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Lipoprotein
(a) Is a Surrogate for Ascorbate (1990)
Rath
M. Proceedings of the National Academy of Sciences, 87: 6204-6207.
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The
concept that lipoprotein(a) is a surrogate for ascorbate is
suggested by the fact that this lipoprotein is found generally
in the blood of primates and the guinea pig, which have lost
the ability to synthesize ascorbate, but only rarely in other
animals. Properties shared with ascorbate, in accordance with
this hypothesis, are the acceleration of wound healing and
of cell repair mechanisms, strengthening of extracellular
matrix (as in blood vessels), and prevention of lipid peroxidation.
Evidence supporting this hypothesis is discussed. |
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Immunological
Evidence for the Accumulation of Lipoprotein(a) in the Atherosclerotic
Lesion of the Hypoascorbemic Guinea Pig (1990)
Rath M. Proceedings of the National Academy of Sciences, 87:
9388-9390.
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Atherosclerosis
was induced in three guinea pigs by dietary ascorbate depletion.
Using SDS/PAGE and subsequent immunoblotting, Lp(a) was identified
as accumulating in the atherosclerotic plaque. Furthermore,
adequate amounts of ascorbate (40 mg/kg body weight/day) prevented
development of atherosclerotic plaques and accumulation of
Lp(a). Guinea pigs were chosen for this study as, similar
to humans, they lack endogenous ascorbate production. |
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Solution
to the Puzzle of Human Cardiovascular Disease: Its Primary
Cause Is Ascorbate Deficiency, Leading to the Deposition of
Lipoprotein(a) and Fibrinogen/Fibrin in the Vascular Wall
(1991)
Rath M, Pauling L. Journal of Orthomolecular Medicine,
6:125-134.
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This
article proposes that human cardiovascular disease is primarily
a degenerative disease, resulting from the accumulation of
lipoprotein(a), which is increased by low ascorbate concentrations.
Ascorbate deficiency results from the inability of humans
to synthesize endogenous ascorbate combined with an insufficient
dietary ascorbate intake. Chronic ascorbate deficiency leads
to extracellular accumulation of lipoprotein(a) and fibrinogen/fibrin,
the hallmarks of the atherosclerotic lesion. |
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Unified
Theory of Human Cardiovascular Disease Leading the Way to
the Abolition of This Disease as a Cause for Human Mortality
(1992)
Rath M, Pauling L. Journal of Orthomolecular Medicine,
7: 5-15.
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In
contrast to current therapeutic approaches, which target individual
pathomechanisms or specific risk factors for CVD, this paper
proposes a unified pathogenetic and therapeutic approach based
on genetic, metabolic, evolutionary and clinical evidence
- ascorbate deficiency. Chronic ascorbate deficiency leads
to loosening of the connective tissue in the vascular wall
and compensatory deposition of Lp(a) (lipoprotein(a)) and
fibrinogen/fibrin. |
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Plasmin-Induced
Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic
Lysine Analogs (1992)
Rath M, Pauling L. Journal of Orthomolecular Medicine,
7:17-23.
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Proteolytic
degradation of extracellular matrix (ECM) by the protease
plasmin is a universal mechanism, determining human health
and disease. Under physiological conditions, this leads to
cell migration and organ remodeling; under pathological conditions,
to sustained degradation of the ECM, as associated with cancer
and viral spread, as well as cardiovascular disease. In this
paper, apoprotein(a), lysine and synthetic lysine analogs
are discussed as inhibitors of plasmin-induced proteolysis
and proposed as natural therapeutic options. |
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Solution
to the Puzzle of Human Evolution (1992)
Rath M. Journal of Orthomolecular Medicine, 7:73-80.
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This
article discusses the rationale for the proposal that the
underlying genetic precondition for the evolution of man was
the loss of endogenous ascorbate production about 40 million
years ago. This genetic mutation became the basis of the dramatic
acceleration of human evolution and a quadruplication of the
brain size in the recent 2.5 million years. Scurvy, the greatest
threat to evolutionary survival of ascorbate-deficient man
during the Ice Age, led to survival genetic features: Lp(a)
for stabilizing the vascular wall and apo(a) to increased
brain size, intelligence and fertility. |
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A
New Era in Medicine (1993)
Rath M. Journal of Orthomolecular Medicine, 8:134-135.
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This
article proposes that, in contrast to the past, the 21st century
will see the eradication of major diseases, such as CVD, and
the establishment of nutritional medicine as an essential
part of the healthcare system. Skepticism and bias against
nutritional supplements will be replaced by acceptance of
vitamins and essential nutrients as safe and affordable preventative
and therapeutic agents, based on an objective scientific attitude
towards nutrient medical research. |
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Books
Matthias Rath, M.D. has authored several popular
health science books that explain the scientific basis of Cellular
Medicine and its subsequent health benefits for the general public.
Dr. Rath’s books have sold millions of copies and have been
translated into ten languages.
Why Animals Don’t Get Heart
Attacks…
But People Do!
by Matthias Rath, M.D.
Why Animals Don’t Get Heart Attacks…But People
Do! documents one of the greatest medical discoveries ever
made. The implementation of Dr. Rath’s vitamin C deficiency-scurvy-heart
disease discovery will lead to the eradication of atherosclerosis,
high cholesterol, high blood pressure, irregular heartbeat
and other cardiovascular conditions naturally. The information
contained on the pages of this international bestseller will
empower you to take control of your cardiovascular health
with side-effect free natural nutrients.
For
ordering information, please click here. |
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Cellular Health™ Series - Cancer
by Matthias Rath, M.D.
Cancer provides a summary of the progress of Cellular Health
in the battle against several forms of cancer, infectious
diseases, and other serious conditions. It substantiates the
fact that cancer - the second most common disease after heart
disease – can be beaten naturally. This book discloses
key mechanisms, which describe how cancer cells spread in
the body and how this process can be blocked in a natural
way. Dr. Rath provides scientific evidence that cancer can
be successfully controlled without chemotherapy, radiation,
or other dangerous and ineffective approaches used today by
conventional medicine.
For
ordering information, please click here. |
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Brochures
Matthias Rath, M.D. and Aleksandra Niedzwiecki,
Ph.D. have authored several popular health science brochures that
explain the scientific basis of Cellular Medicine and its subsequent
health benefits for the general public.
Cellular Nutrient Synergy in Health
by Aleksandra Niedzwiecki, Ph.D. and Matthias Rath, M.D.
This brochure describes how the biochemical systems within
the body operate under the law of synergy. It is important
to remember that no single nutrient works alone in the body.
Taking too much of one nutrient in isolation can have a powerful
and potentially disruptive influence on the mechanisms that
regulate our biochemistry.
To download brochure,
please click here. |
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Malnutrition: The Leading Cause of
Immune Deficiency Diseases Worldwide
by Aleksandra Niedzwiecki, Ph.D. and Matthias Rath, M.D.
In the developing world, the primary health-related problems
are widespread malnourishment, micronutrient deficiencies
and sanitation. However, instead of directing funds to cope
with these major problems, the governments of these countries
are under pressure by pharmacological multinationals to import
their drugs. This brochure outlines the scope of the problem
– and its solutions.
To download brochure,
please click here. |
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The Natural Control of HIV/AIDS Is
in Sight!
by Matthias Rath, M.D. and Aleksandra Niedzwiecki, Ph.D.
The dramatic results of a clinical pilot project conducted
on HIV/AIDS patients in South Africa showed that a micronutrient
program could reverse the course of HIV/AIDS after just four
weeks in people who had never taken anti-retroviral (ARV)
drugs. This brochure outlines clinical evidence supporting
the benefits of nutrients in AIDS cases.
To download brochure,
please click here. |
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