The Latest Scientific Research

Scientific Publications

Published In: Experimental Lung Research, 2006 Nov-Dec; 32(10):517-530.
Inhibition of Pulmonary Metatasis of Melanoma B16FO Cells in C57BL/6 Mice by a Nutrient Mixture Consisting of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, and M. Rath
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Published In: Experimental Lung Research, 32:69-79, 2006.
In Vivo and In Vitro Anti-tumor Effect of a Unique Nutrient Mixture on Lung Cancer Cell Line A-549
M.Waheed Roomi, Vadim Ivanov, Tatiana Kalinovsky, Aleksandra Niedzwiecki, and Matthias Rath
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Published In: Journal of Obstetrics and Gynecology, 2006; 32(2):148-154.
Inhibition of Matrix Metalloprotenase-2 Secretion and Invasion by Human Ovarian Cancer Line SK-OV-3 with Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and M. Rath
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Published In: Oncology Reports , 2006; 16(5):943-7.
Anticancer Effect of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract on Human Renal Adenocarcinoma Line 786-0
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and M. Rath
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Published In: Medical Oncology, vol.23, no.3, 411-417, 2006.
Effect of Ascorbic Acid, Lysine, Proline and Green Tea Extract on Human Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: JANA, vol.9, no.2, 30-34, 2006.
In Vitro and In Vivo Antitumor Effect of a Nutrient Mixture Containing Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Synovial Sarcoma Cancer Cells
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: Experimental Lung Research, 32:69-79, 2006.
Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production and Invasion by a Novel Nutrient mixture
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: Int J Gynecol Cancer 2006, 16, 1241-1247.
Suppression of Human Cervical Cancer Cell Lines Hela and DoTc2 4510 MMP Expression and Matrigel Invasion by a mixture of lysine, proline, ascorbic acid, and green tea extract
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: International Journal of Urology 2006; 13:413-417.
Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract on Bladder Cancer Cell Line T-24
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: Medical Oncology 2006; 23(2):245-250.
Modulation of Human Renal Cel Carcinoma 786-0 MMP-2 and MMP-9 Activity by Inhibitors and Inducers in Vitro
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: In Vivo – 2006;20(1):25-32.
In Vitro and In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, And Green Tea Extract On Human Melanoma Cell Line A2058
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: Journal of Obstetrics and Gynaecology Research –2006, 32(1):23-31
Natural Nutrient Mixture Effectively Reduces Collagen Matrix Contraction Driven by Human Uterine Smooth Muscle Cells
V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: Oncology Reports – Dec;14(6):1399-404.
Antiangiogenic Effects of a Nutrient Mixture on Human Umbilical Vein Endothelial Cells
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
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Published In: Leukemia Research 30, (2006) 869-881.
Apoptosis Induction by Nutrient Synergy in HTLV-1 Positive and Negative Malignant T-Cells
S. Harakeh, M. Diab-Assaf, A. Niedzwiecki, J. Khalife, K. Abu-El-Ardat, M. Rath
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Published In: The Journal of Cardiovascular Pharmacology – 2005, 46(5):570-6
Bioflavonoids Effectively Inhibit Smooth Muscle Cell-Mediated Contraction of Collagen Matrix Induced by Angiotensin II
V.Ivanov, M.W. Roomi, T.Kalinovsky, A. Niedzwiecki, M. Rath
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Scientific Presentations

Presented at: 76th Congress of the European Atherosclerosis Society; Helsinki, Finland; June 10-13, 2007
Published in: Atherosclerosis Supplements, volume 8, issue 1, June 2007, page 163, poster #P020-598
Plant-Derived Nutrients Inhibit Monocyte Retention By Extracellular Matrix Produced By Aortic Smooth Muscle and Endothelial Cells
Vadim Ivanov, Svetlana Ivanova, M. Waheed Roomi, Aleksandra Niedzwiecki, Matthias Rath.
Dr Rath Research Institute, Santa Clara, California, USA

Presented at: 8th World Congress in Inflammation; Copenhagen, Denmark; June 16-20, 2007
Published in: Inflammation Research, volume 56, supplement 3, June 2007, page S471
Poster #P12.05
Essential Nutrients Suppress Inflammation By Modulating Key Inflammatory Gene Expression
V. Ivanov, J. Cha, S. Ivanova, M.W.Roomi, A. Niedzwiecki, M.Rath.
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050

Presented at: International Congress of Toxicology, Montreal, Canada, July 15-19, 2007
Published in: International Congress of Toxicology, Carcinogenesis, July 2007, Abstract #PW2.042,page 84
Antineoplastic Activity of a Novel Nutrient Mixture on Malignant Retinoblastoma Cell Line Y79
M. Waheed Roomi, Vadim Ivanov, Aleksandra Niedzwiecki, Matthias Rath.
Dr Rath Research Institute, Santa Clara, California, USA

Presented at: 98th Annual Meeting of the AACR, Los Angeles, CA, April 14-18, 2007
Published in: Proceedings of the 98th Annual Meeting of the AACR, Abstract #559, p 114
Pattern of MMP-2 and MMP-9 Secretion in Human Cancer Cell Lines
M.W. Roomi, J. Monterrey, V. Ivanov, A. Niedzwiecki and M. Rath

Presented at: 98th Annual Meeting of the AACR, Los Angeles, CA, April 14-18, 2007
Published in: Proceedings of the 98th Annual Meeting of the AACR, Abstract #2634, p 231
Inhibition of 7,12-Dimethylbenzanthracene-Induced Skin Tumor by a Nutrient Mixture
M.W. Roomi, N.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath

Presented at: 46th Annual Meeting of Society of Toxicology, Charlotte, NC, March 25-29, 2007
Published in: The Toxicologists (suppl Toxicological Sciences), Abstract #1001, pg 207, 2007.
Isoniazid Induces Apoptosis and Inhibits MMP Secretion in Human Hepatoma Cell Line SK-Hep- 1
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: 46th Annual Meeting of the Society of Toxicology; Charlotte, NC; March 25-29, 2007
Published in: The Toxicologists (suppl Toxicological Sciences), Abstract #610, pg 126, 2007.
A Novel Nutrient Mixture Inhibits Cell Proliferation, MMP Secretion and Invasion in HepG2 Hepatoma Cell Line
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: GTCbio Apoptosis in Drug Discovery; San Diego, CA; March 22-23, 2007
Published in: Proccedings of the GTCbio Conference on Apoptosis in Drug Discovery
A Novel Nutrient Mixture Induces Apoptosis in Human Prostate Cancer Cell Line Du-145
M.W. Roomi, N.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath

Presented at: GTCbio Apoptosis in Drug Discovery; San Diego, CA; March 22-23, 2007
Published in: Proceedings of the GTCbio Conference on Apoptosis in Drug Discovery
Apoptosis of Human Cervical and Ovarian Cancer Cell Lines Induced by a Novel Nutrient Mixture
M.W. Roomi, N.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath

Presented at: 46th Annual Meeting of The American Society for Cell Biology, San Diego December 9-13, 2006
Published in: 46th Annual Meeting of The American Society for Cell Biology, San Diego, December 9-13, 2006 Proceedings, Abstract # 1280.
Suppression of Growth In Vivo and In Vitro of Murine B16FO Melanoma Cells by a Novel Nutrient Mixture
M.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath

Presented at: 21st Annual Meeting of the ISBTC, October 26-29, 2006, Los Angeles, CA
Published in: Proceedings of the 21st Annual Meeting of the ISBTC, abstract #116.
Inhibition of Human Neuroblastoma Cell Line SK-N-MC In Vivo and In Vitro By a Novel Nutrient Mixture
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, November 7-10, 2006, Prague, Czechoslovakia
Published in: The European Journal of Cancer 2006, vol 4(12), abstract #520.
Marked Inhibition of Tumor Growth, MMP Secretion and Invasion by a Nutrient Mixture on Head and Neck Squamous Carcinoma Cell Line FaDu: In Vitro and In Vivo Studies
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: 18th Annual Fanconi Anemia Research Fund Scientific Symposium, October 19-22, 2006, Bethesda, Maryland
Published in: 18th Annual Fanconi Anemia Research Fund Scientific Symposium proceedings, pg 64
In Vitro Inhibition of MMPS, Invasion and Growth of Human Fanca and Fancc Lymphoblasts by a Unique Nutrient Mixture
M.W.Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: 47th Annual Meeting of the American College of Nutrition, October 5-8, 2006, Reno, NV
Published in: Journal of the American College of Nutrition vol 25(5), October 2006, abstract #23
Inhibition of Hemangioendothelioma In Vivo and Invasion and Growth In Vitro by a Unique Nutrient Mixture
M.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath

Presented at: AICR International Research Conference on Food, Nutrition and Cancer, July 13-14, 2006, Washington DC
Published in: AICR International Research Conference on Food, Nutrition and Cancer Poster Abstract Book, Abstract #42
Inhibitory Effect of a Novel Nutrient Mixture on MMP Secretion and Invasion on Human Thyroid Cancer Cell Line SW 579: In Vitro Study
M.W. Roomi, N.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath

Presented at: 97th Annual Meeting of the AACR, Washington D.C., April 1-5, 2006
Published in: Proceedings of the 97th Annual Meeting of the AACR, Abstract #1915
Antineoplastic Effect of Nutrient Mixture on Human Burkitt’s Lymphoma Raji Cells
M.W. Roomi, N.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath

Presented at: 97th Annual Meeting of the AACR, Washington DC, April 1-5, 2006
Published in: Proceedings of the 97th Annual Meeting of the AACR, Abstract #1903
A Nutrient Mixture Consisting of Lysine, Proline, Ascorbic Acid and Green Tea Extract Inhibit Lung Metastasis by B16FO Melanoma Cells in Mice
M.W. Roomi, N.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: FASEB, San Francisco, CA, April 1-5, 2006
Published in: The FASEB Journal, Abstract #107
Antileukemic Effect of a Novel Nutrient Mixture on Human JURKAT T Cells
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: FASEB, San Francisco, CA, April 1-5, 2006
Published in: The FASEB Journal, Abstract 85
A Nutrient Mixture Suppresses Carbon Tetrachloride Induced Hepatic Toxicity in ICR Mice
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: Society of Toxicology, San Diego, CA, March 5-9, 2006
Published in: The Toxicologists (suppl Toxicological Sciences) 90 (1), Abstract 1398, pg 285, 2006.
A Nutrient Mixture Attenuates Acetaminophen Hepatic and Renal Toxicity in ICR
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented At: International Research Conference on Food, Nutrition, and Cancer, Washington, DC, July 14-15, 2005
Published In: Poster Abstract Book, Abstract # 36
Inhibition of Cell Invasion and MMP Production by a Nutrient Mixture in Malignant Liposarcoma Cell Line SW-872
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented At: Directions and Needs in Asbestos Research, University of Montana, July 28-29, 2005
Published In: Conference proceedings
Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production and Invasion by a Novel Nutrient Supplement
M.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath

Presented At: 2nd International Conference on Tumor Progression & Therapeutic Resistance, Boston, September 18-20, 2005
Published In: 2nd International Conference on Tumor Progression & Therapeutic Resistance Proceedings, page 89.
Studies on the Bioehancing Effects of Red Onions and other Nutrients on the Absorption of Epigallocatechin Gallate from Green Tea Extract in Human Volunteers
Anup Kale1, Sonia Gawande1, Swati Kotwal1, Shrirang Netke2, Waheed Roomi2, Vadim Ivanov2, Aleksandra Niedzwiecki2 and Matthias Rath2
1 Post Graduate Department of Biochemistry, University of Nagpur, Nagpur, M.S. 440033, India
2 Dr Matthias Rath Institute of Cellular Research,1260 Memorex Drive, Santa Clara, CA 95050, US

Presented At: 46th Annual Meeting of the American College of Nutrition, Charleston, South Carolina, Sept 22-25, 2005
Published In: Journal of the American College of Nutrition, vol 24(5), Oct 2005, abstract #75
Novel Anticarcinogenic Effect of a Nutrient Mixture: Inhibition of MMPs, Invasion and Growth of Human Rhabdomyosarcoma in vitro
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented At: 17th Annual Fanconi Anemia Scientific Symposium, Geneva, Switzerland, September 29- October 2, 2005
Published In: 17th Annual Fanconi Anemia Scientific Symposium Proceedings, Poster #110
Down Regulation of Matrix Metalloproteinases and Inhibition of Cell Invasion by a Novel Nutrient Mixture in Human FA Fibroblast Cell Lines: in vitro Study
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented At: 2nd International Tumor Metabolism Summit, Genova, Italy, October 7-8, 2005
Published In: 2nd International Tumor Metabolism Summit Proceedings
A Novel Nutrient Mixture as an Antileukemic Agent with Matrix Metalloproteinase and Invasion Inhibitory Activities
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented At: 10th World Congress on Advances in Oncology and 8th International Symposium on Molecular Medicine, Crete, Greece, October 13-15, 2005.
Published In: International Journal of Molecular Medicine, abstract #121, page S10.
Inhibitory Effect of a novel mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in cancer progression
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath

Presented At: International Academy of Cardiology, 12th World Heart Congress, New Trends in Research, Diagnosis, and Treatment Vancouver, B.C., Canada, July 16-19, 2005
Published In: The Journal of Heart Disease; vol 4(1): 99, Abstract #394
Mixture of Natural Nutients Reduces Collagen Matrix Contraction Driven by Aortic Smooth Muscle Cells
V. Ivanov, S. Ivanova, M.W. Roomi, A. Niedzwiecki, M. Rath

Presented At: 46th Annual Meeting of the American College of Nutrition, Charleston, South Carolina, Sept 22-25, 2005.
Published In: Journal of the American College of Nutrition, vol 24(5), Oct 2005, abstract #74
Nutrient Mixture Prevents Hyper-Reactive Response of Bronchial Muscle to Inflammatory and Allergic Stimuli.
v. Ivanov, M.W. Roomi, A. Niedzwiecki, M. Rath