Cellular Medicine Concept Publications

	Lipoprotein (a) Is a Surrogate for Ascorbate (1990) M. Rath. Proceedings of the National Academy of Sciences, 87: 6204-6207.	View full paper	View in PDF
	The concept that lipoprotein(a) is a surrogate for ascorbate is suggested by the fact that this lipoprotein is found generally in the blood of primates and the guinea pig, which have lost the ability to synthesize ascorbate, but only rarely in other animals. Properties shared with ascorbate, in accordance with this hypothesis, are the acceleration of wound healing and of cell repair mechanisms, strengthening of extracellular matrix (as in blood vessels), and prevention of lipid peroxidation. Evidence supporting this hypothesis is discussed.
	Solution to the Puzzle of Human Cardiovascular Disease: Its Primary Cause Is Ascorbate Deficiency, Leading to the Deposition of Lipoprotein(a) and Fibrinogen/Fibrin in the Vascular Wall (1991) M. Rath, L. Pauling. Journal of Orthomolecular Medicine, 6:125-134.	View full paper	View in PDF
	This article proposes that human cardiovascular disease is primarily a degenerative disease, resulting from the accumulation of lipoprotein(a), which is increased by low ascorbate concentrations. Ascorbate deficiency results from the inability of humans to synthesize endogenous ascorbate combined with an insufficient dietary ascorbate intake. Chronic ascorbate deficiency leads to extracellular accumulation of lipoprotein(a) and fibrinogen/fibrin, the hallmarks of the atherosclerotic lesion.
	Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of This Disease as a Cause for Human Mortality (1992) M. Rath, L. Pauling. Journal of Orthomolecular Medicine, 7: 5-15.	View full paper	View in PDF
	In contrast to current therapeutic approaches, which target individual pathomechanisms or specific risk factors for CVD, this paper proposes a unified pathogenetic and therapeutic approach based on genetic, metabolic, evolutionary and clinical evidence - ascorbate deficiency. Chronic ascorbate deficiency leads to loosening of the connective tissue in the vascular wall and compensatory deposition of Lp(a) (lipoprotein(a)) and fibrinogen/fibrin.
	Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs (1992) M. Rath, L. Pauling. Journal of Orthomolecular Medicine, 7:17-23.	View full paper	View in PDF
	Proteolytic degradation of extracellular matrix (ECM) by the protease plasmin is a universal mechanism, determining human health and disease. Under physiological conditions, this leads to cell migration and organ remodeling; under pathological conditions, to sustained degradation of the ECM, as associated with cancer and viral spread, as well as cardiovascular disease. In this paper, apoprotein(a), lysine and synthetic lysine analogs are discussed as inhibitors of plasmin-induced proteolysis and proposed as natural therapeutic options.
	Solution to the Puzzle of Human Evolution (1992) M. Rath. Journal of Orthomolecular Medicine, 7:73-80.	View full paper	View in PDF
	This article discusses the rationale for the proposal that the underlying genetic precondition for the evolution of man was the loss of endogenous ascorbate production about 40 million years ago. This genetic mutation became the basis of the dramatic acceleration of human evolution and a quadruplication of the brain size in the recent 2.5 million years. Scurvy, the greatest threat to evolutionary survival of ascorbate-deficient man during the Ice Age, led to survival genetic features: Lp(a) for stabilizing the vascular wall and apo(a) to increased brain size, intelligence and fertility.
	A New Era in Medicine (1993) M. Rath. Journal of Orthomolecular Medicine, 8:134-135.	View full paper	View in PDF
	This article proposes that, in contrast to the past, the 21st century will see the eradication of major diseases, such as CVD, and the establishment of nutritional medicine as an essential part of the healthcare system. Skepticism and bias against nutritional supplements will be replaced by acceptance of vitamins and essential nutrients as safe and affordable preventative and therapeutic agents, based on an objective scientific attitude towards nutrient medical research.

Experimental Research:

	Heart Disease Bioflavonoids Effectively Inhibit Smooth Muscle Cell-Mediated Contraction of Collagen Matrix Induced by Angiogtensin-II V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath. The Journal of Cardiovascular Pharmacology (2005), 46(5): 570-6.	View summary	View in PDF
	Reduction In The Frequency Of Arrhythmic Epidsodes In Patients With Paroxysmal Atrial Arrhythmia With A Vitamin/Essential Nutrient Program M. Rath T. Kalinovsky, A. Niedzwiecki. JANA (2005), 8(3): 21-25.	View summary	View in PDF
	Extracellular Matrix-Mediated Control of Smooth Muscle Cell Growth and Migration by a Combination of Ascorbic Acid, Lysine, Proline and Catechins V. Ivanov, S. Ivanova, M.W. Roomi, A. Niedzwiecki, M. Rath. Matthias Rath BV - Santa Clara, CA. Atherosclerosis (2005), vol. 6, issue 1, p.18.	View summary
	Enhancement of Cardio-Protective Effects and Attenuation of Adverse Effects of Female Sex Hormones on Cultured Human Vascular Smooth Muscle Cells by a Combination of Ascorbic Acid, Lysine, Proline, Arginine, Cysteine, and Epigallocatechin Gallate V. Ivanov, S. Ivanova, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath. JANA (Jan.2005), 7(3): 17-22.	View summary	View in PDF
	A Nutrient Mixture Containing Ascorbic Acid, Lysine, Proline, Arginine, Cysteine, and Green Tea Extract Suppresses Autocrine Inflammatory Response in Cultured Human Aortic Smooth Muscle Cells V. Ivanov, S. Ivanova, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath. Research Communications in Pharmacology Toxicology (2004), 9: 3-16.	View summary
	Nutritional Supplement Program Halts Progression of Early Coronary Atherosclerosis Documented by Ultrafast Computed Tomography M. Rath, A. Niedzwiecki. Journal of Applied Nutrition (1996), 48: 68-78.	View full paper	View in PDF
	Lipoprotein(a) Reduction by Ascorbate M. Rath. Journal of Orthomolecular Medicine (1992), 7: 81-82.	View full paper
	Anti-Atherosclerotic Effect of Probucol in WHHL Rabbits: Are There Plasma Parameters to Evaluate this Effect? B. Finckh, A. Niendorf, M. Rath, U. Beisiegel. European Journal of Clinical Pharmacology (1991), 40: 77-80.	View full paper	View in PDF
	Immunological Evidence for the Accumulation of Lipoprotein(a) in the Atherosclerotic Lesion of the Hypoascorbemic Guinea Pig M. Rath, L. Pauling. Proceedings of the National Academy of Sciences USA (1990), 87: 9388-9390.	View full paper	View in PDF
	Lipoprotein(a) in the Arterial Wall U. Beisiegel, A. Niendorf, K. Wolf, T. Reblin, M. Rath. European Heart Journal 11 (1990), (Supp. E): 174-83.	View full paper	View in PDF
	Morphological Detection and Quantification of Lipoprotein(a) Deposition in Atheromatous Lesions of Human Aorta and Coronary Arteries A. Niendorf, M. Rath, K. Wolf, S. Peters, H. Arps, U. Beisiegel. Virchow's Archive of Pathological Anatomy (1990), 417: 105-111.	View full paper	View in PDF
	Detection and Quantification of Lipoprotein(a) in the Arterial Wall of 107 Coronary Bypass Patients M. Rath, A. Niendorf, T. Reblin, M. Dietel, HJ Krebber, U. Beisiegel. Arteriosclerosis (1989), 9: 579-592.	View full paper	View in PDF

Cancer:

	Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production and Invasion by a Novel Nutrient mixture M.W. Roomi, V. Ivanonv, T. Kalinovsky, A. Niedzwiecki, M. Rath. Experimental Lung Research (2006), 32: 69-79.	View full paper	View in PDF
	Suppression of Human Cervical Cancer Cell Lines Hela and DoTc2 4510 MMP Expression and Matrigel Invasion by a mixture of lysine, proline, ascorbic acid, and green tea extract M.W. Roomi, V. Ivanonv, T. Kalinovsky, A. Niedzwiecki, M. Rath. Int. J Gynecol Cancer (2006), 16: 1241-1247.	View full paper	View in PDF
	Anti-tumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract on Bladder Cancer Cell Line T-24 M.W. Roomi, V. Ivanonv, T. Kalinovsky, A. Niedzwiecki, M. Rath. International Journal of Urology (2006), 13: 413-417.	View full paper	View in PDF
	Modulation of Human Renal Cell Carcinoma 786-0 MMP-2 and MMP-9 Activity by Inhibitors and Inducers in Vitro M.W. Roomi, N. Roomi, V. Ivanov,T. Kalinovsky, A. Niedzwiecki, M. Rath. Medical Oncology (2006), 23(2): 245-250.	View full paper	View in PDF
	Inhibition of MMP-2 Secretion and Invasion by Human Ovarian Cancer Cell Line SK-OV-3 with Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Journal of Obstetrics and Gynecology Research (2006), 32,141-147.	View full paper	View in PDF
	In Vivo and In Vitro Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract on Human Fibrosarcoma Cells HT-1080 M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Medical Oncology (2006), 23(1): 105-112.	View full paper	View in PDF
	In Vitro and In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, And Green Tea Extract On Human Melanoma Cell Line A2058 M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. In Vivo (2006), 20(1): 25-32.	View full paper	View in PDF
	Apoptosis Induction by Nutrient Synergy in HTLV-1 Positive and Negative Malignant T-Cells S. Harakeh, M. Diab-Assaf, A. Niedzwiecki, J. Khalife, K. Abu-El-Ardat, M. Rath. Leukemia Research 30 (2006), p.869-881.	View full paper	View in PDF
	Inhibitory Effect Of A Mixture Containing Ascorbic Acid, Lysine, Proline, And Green Tea Extract On Critical Parameters In Angiogenesis M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Oncology Reports (2005), 14(4): 807-815.	View full paper	View in PDF
	In Vitro and In Vivo Antitumorigenic Activity of a Mixture of Lysine, Proline, Ascorbic Acid and Green Tea Extract on Human Breast Cancer Lines MDA MB-231 and MCF-7 M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Medical Oncology (2005), 22(2): 129-38.	View full paper	View in PDF
	Antitumor Effect of a Combination of Lysine, Proline, Arginine, Ascorbic Acid, and Green Tea Extract on Pancreatic Cancer Cell Line MIA PaCa-2 M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. International Journal of Gastrointestinal Cancer (2005), 35(2): 97-102.	View full paper	View in PDF
	Antitumor Effect of Nutrient Synergy on Human Osteosarcoma Cells U2OS, MNNG-HOS, and Ewing’s Sarcoma SK-ES.1 M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Oncology Reports (2005), 13(2): 253-257.	View full paper	View in PDF
	Modulation of N-Methyl –N-Nitrosourea-Induced Mammary Tumors in Sprague-Dawley Rats by Combination of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract M.W. Roomi, V. Ivanov ,T. Kalinovsky, A. Niedzwiecki, M. Rath. Breast Cancer Research (2005), 7: R291-R295.	View full paper	View in PDF
	In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Prostate Cancer PC-3 Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. In Vivo (2005), 19(1): 179-184.	View full paper	View in PDF
	In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Colon Cancer Cell HCT 116 Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Oncology Reports (2005), 12(3): 421-425.	View full paper	View in PDF
	Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine and Epigallocatechin Gallate in Prostate Cancer Cell Lines PC-3, LNCaP, and DU145 M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Research Communications in Molecular Pathology and Pharmacology (2004), 115, 1-6.	View full paper	View in PDF
	Synergistic Effect of Combination of Lysine, Proline, Arginine, Ascorbic Acid and Epigallocatechin Gallate on Colon Cancer Cell Line HCT 116 M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Journal of the American Nutraceutical Association (2004), 7(2): 40-43.	View full paper	View in PDF
	In Vivo and In Vitro Antitumor Effect of Nutrient Synergy on Human Osteosarcoma Cell Line MNNG-HOS M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Annals of Cancer Research and Therapy (2004), 12(1&2): 135-145.	View full paper	View in PDF
	Synergistic Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Epigallocatechin Gallate on Human Fibrosarcoma Cells HT-1080 M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Annals of Cancer Research and Therapy (2004), 12(1&2): 146-156.	View full paper	View in PDF
	A Specific Combination of Ascorbic Acid, Lysine, Proline and Epigallocatechin Gallate Inhibits Proliferation and Extracellular Matrix Invasion of Various Human Cancer Cell Lines S. Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath. Research Communications in Pharmacology and Toxicology Emerging Drugs (2003), 2: 37-5.	View full paper	View in PDF
	Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs M. Rath, L. Pauling. Journal of Orthomolecular Medicine (1992), 7: 17-23.	View full paper	View in PDF

Other Research

	Natural Nutrient Mixture Effectively Reduces Collagen Matrix Contraction Driven by Human Uterine Smooth Muscle Cells V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M.Rath. Journal of Obstetrics and Gynecology Research (2006), 32(1): 23-31.	View full paper	View in PDF
	Anti-Angiogenic Effects of a Nutrient Mixture on Human Umbilical Vein Endothelial Cells M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath. Oncology Reports (2005), 14: 1399-1404.	View full paper	View in PDF
	Reduction in Tibial Shaft Fracture Healing Time With Essential Nutrient Supplementation Containing Ascorbic Acid, Lysine, and Proline Jamdar J, Rao B, Netke S, Roomi MW, Ivanov V, Niedzwiecki A, Rath M. “Letter to the Editor” - Journal of Alternative and Complementary Medicine (2004), 10(6), 915-916.	View full paper	View in PDF
	Antioxidant Supplements and Simvastatin-Niacin Therapy S. Netke, V. Ivanov, M.W. Roomi, A. Niedzwiecki, M. Rath. “Letter to the Editor” - Arteriosclerosis, Thrombosis and Vascular Biology (2001), Vol. 21, No.12, p.2099-2100.	View full paper	View in PDF

Books Published

1.	Eradicating Heart Disease
2.	Why Animals Don't Get Heart Attacks But People Do
3.	Good Health - Do It Yourself!
4.	Cellular Health Series: The Heart
5.	Cellular Health Series: Cancer
6.	Cellular Health Series: Ten Years That Changed Medicine Forever
7.	Cellular Health Series: Health for the 21st Century
8.	The Cellular Health Solution to Irregular Heartbeat: Results of a Randomized, Double-Blind Placebo-Controlled Clinical Study